Pathogenetic basis of diagnosis of disseminated intravascular coagulation syndrome in shock

Changes in the hemostasis system under extreme influences on the body have for many years been the subject of close attention of clinicians and pathologists. Particular interest in this problem is due to the most frequent in practice set of disorders known as disseminated intravascular coagulation (synonyms: thrombohemorrhagic syndrome, consumption coagulopathy, secondary fibrinolysis, hypofibrinogenemia, coagulopathic syndrome, etc.). Based on the modern concepts of shock as a process based on systemic disruption of microhemocirculation with inadequate tissue oxygenation and impaired cellular metabolism, the pathogenetic role of DIC becomes particularly significant.