Determination of 5´-nucleotidase activity of cerebrospinal fluid for the diagnosis of cerebral thrombosis

One of the reserves for improving the effectiveness of treatment of severe craniocerebral trauma is the timely diagnosis of foci of cerebral hemorrhage and their surgical removal. However, the most common diagnostic methods (echoencephalography, electroencephalography, cerebral angiography) do not always allow differential diagnosis of foci of cerebral crush and foci of cerebral contusion. It can be assumed that in severe isolated closed craniocerebral trauma accompanied by foci of cerebral crush injuries, cerebral detritus in the form of cell membrane fragments will appear in the cerebrospinal fluid. Their reliable verification may become a valid diagnostic test for cerebral crush foci. We believe that the 5'-nucleotidase enzyme, firmly bound to the outer surface of the plasma membranes, can serve as a marker of cellular destruction.