Open AccessEffect of a preparation of medical leeches (Hirudo medicinalis) on phagocytosis and the complement system
Author(s) -
I. P. Baskova,
G I Nikonov,
E. G. Mirkamalova,
В.В. Зинченко,
Л. В. Козлов
Publication year - 1988
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj98427
Subject(s) - hirudin , kallikrein , platelet , chemistry , hirudo medicinalis , cyclase , biochemistry , secretion , fibrin , adenylate kinase , hemostasis , prothrombinase , enzyme , thrombin , microbiology and biotechnology , pharmacology , biology , leech , immunology , medicine , world wide web , computer science
Except such known inhibitors of proteolytic enzymes, as hirudin, bdellins and eglins, and also hyaluronidase enzyme, by us in a secretion of salivary glands of medical leeches the new enzyme destabilase which breaks isopeptide bonds in stabilized fibrin and having thrombolytic action, inhibitor of blood plasma kallikrein and prostanoids, on a spectrum of action similar to prostacycline and its stable analogues have been found. We show that the secret of leeches irrespective of presence in it hirudin suppresses platelet-vascular hemostasis, interfering adhesion of platelets on a surface of collagen and the aggregation of the platelets stimulated by inductors of various nature, by activation of adenylate cyclase of membranes of platelets [3]. Irrespective of the presence of hirudin, the secret blocks the contact stage of the internal mechanism of blood coagulation by inhibiting blood plasma kallikrein and Hagemann factor.