Open AccessStudy of the local irritating effect of suppositories with gabutamine
Author(s) -
С. А. Сидуллина,
P. P. Dementieva
Publication year - 2022
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj96302
Subject(s) - pharmacology , hydrochloride , anticonvulsant , chemistry , medicine , organic chemistry , epilepsy , psychiatry
In the practice of anticonvulsant therapy, a significant arsenal of drugs is used. In recent years, it has been established that nitrogen-containing derivatives of trichloromethylpropanoic acid are mainly low-toxic compounds with pronounced anticonvulsant and anti-tremor effects. Among them, one can distinguish a new original biologically active substance habutamine - 1,3dichloro-2-chloromethylaminopropane hydrochloride, obtained at the Kazan Research Institute of Chemical Products. Based on the pharmacological effect of gabutamine, studied at the Department of Pharmacology of the KSMU, and the possibility of its use in all age groups, a rational dosage form was proposed - rectal suppositories.