Malignant tumors of the thyroid gland and their relation to goiter in man and animals. Wegelin (Cancer Review, 1928, No. 7)

In both humans and animals, a close affinity between endemic goiter and malignant thyroid tumors has been definitely established. Here almost invariably malignant changes originate from benign tissue proliferations. Thus, Wegelin points out that, for example, in Berlin, which is almost free of goiter disease, malignant thyroid tumors account for no more than 0.09% of the sectional material, whereas in Bern, which is the area where endemic goiter reaches its maximum in Europe, the same tumors account for 1.04%.