Open AccessThe effect of specific inhibition of Hageman factor on contact-activated fibrinolysis
Author(s) -
I. M. Baishev
Publication year - 1984
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj89238
Subject(s) - fibrinolysis , factor xii , zymogen , proteolysis , chemistry , kallikrein , plasmin , biochemistry , coagulation , medicine , enzyme
Highly purified factor XII zymogen (Hageman factor) of human blood plasma, when bound to a foreign surface, is capable of self-activation by intramolecular proteolysis. The resulting active Hageman factor stimulates blood clotting along the internal and external pathways, kininogenesis and fibrinolysis. The aim of our work was to study contact-induced fibrinolysis with selective inhibition of factor XIIa in blood plasma.