The effect of specific inhibition of Hageman factor on contact-activated fibrinolysis

Highly purified factor XII zymogen (Hageman factor) of human blood plasma, when bound to a foreign surface, is capable of self-activation by intramolecular proteolysis. The resulting active Hageman factor stimulates blood clotting along the internal and external pathways, kininogenesis and fibrinolysis. The aim of our work was to study contact-induced fibrinolysis with selective inhibition of factor XIIa in blood plasma.