Open AccessClinical significance of the study of the platelet link of hemostasis in viral hepatitis
Author(s) -
S. N. Sorinson,
V. E. Kozulin
Publication year - 1983
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj88002
Subject(s) - hemostasis , fibrinolysis , platelet , coagulation , viral hepatitis , fibrinogen , medicine , immunology , platelet activation , hepatitis
The decisive importance in the pathogenesis of hemostasis disorders in viral hepatitis is mainly attributed to a decrease in the content of plasma coagulation factors. The development of an extensive cytolytic process in the liver explains the violation of the synthesis of prothrombin, proaccelerin, proconvertin, partially fibrinogen, a disorder of the regulation of fibrinolysis [1, 4]. Changes in the platelet link of hemostasis in viral hepatitis are completely insufficiently covered in the literature [5, 10]. At the same time, it is known that at the initial stages of hemostasis disorders, it is the platelet link that plays the leading role. This is due to angiotrophic (maintaining the normal state of microvascular walls), adhesive-aggregation (the property of forming a primary platelet plug), concentration-transport (adsorption of many coagulation factors) functions, the ability to maintain microvascular spasm and inhibitory effect on fibrinolysis [2].