Toxic epidermal necrolysis (Lyell's syndrome)

In recent years, descriptions of cases of toxic epidermal necrolysis - Lyell's syndrome in children - have increasingly appeared in the periodical literature. Most authors consider this disease as a toxic-allergic reaction to various medicinal substances: antibiotics, sulfa drugs, etc. Cases of Lyell's syndrome in children after administration of measles and tetanus toxoid are described. The prognosis of the disease is difficult: 30% are fatal. Patients die from toxicosis at the height of the disease or from septic complications.