Open AccessChange of zinc homeostasis in kidney diseases in children
Author(s) -
Т. П. Макарова
Publication year - 2001
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj83861
Subject(s) - zinc , reabsorption , excretory system , homeostasis , kidney , excretion , endocrinology , medicine , zinc deficiency (plant disorder) , immunity , biology , renal physiology , chemistry , immune system , immunology , organic chemistry
The zinc metabolism in kidney pathology in children is studied. The decrease of serum zinc level connected with its increased excretion, that is identified as deficiency of the excretory type, is revealed. The effect of the increased zinc excretion on the functional state of proximal tubules, tested by the level of aminoaciduria and phosphate reabsorption, as well as on the function of distal tubules, determined by the processes of acido- and ammoniogenesis, is established. The depressive effect of zinc on cellular and humoral immunity links as well as on phagocytic activity of neutrophiles, that is identified as dificiency of immunologic consumption, is established.