To the treatment of idiopathic epilepsy with the introduction of bromine into the spinal canal

In an effort to alleviate the situation of patients with epilepsy, and proceeding from the considerations that bromine, like most other medications taken per os, undergoes various metamorphoses before absorption and enters the bloodstream in the form of completely unknown chemical compounds to us, we decided to inject bromine into epileptics into the spinal canal, where this drug would immediately enter the cerebrospinal fluid without preliminary chemical changes. Since 1926, we have treated 25 cases of idiopathic epilepsy since 1926: 22 men. and 3 women All patients undergoing treatment suffered from frequent seizures (once or even several times a day, one with status erilepticus) and only once a month. We injected into the spinal canal 5% and 10% sodium bromide from 5.0 to 10.0. Before introducing the bromide solution, we previously released at least the same amount of cerebrospinal fluid; for the most part we released twice as many liqs. cer. spin. than Sol. natr. bromati, since in most cases the pressure was noticeable, and sometimes strongly, increased. A sterile solution of sodium bromide was injected into the spinal canal with a syringe through the Birov trocar between the 4th and 5th lumbar vertebrae. Each patient was punctured once a week.