Open AccessThe use of nibufin for fractures of tubular bones
Author(s) -
U. Ya. Bogdanovich,
Ф Ш Бахтиозин,
В. П. Прохоров
Publication year - 1969
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj79836
Subject(s) - smooth muscle , peristalsis , chemistry , uterus , pharmacology , anatomy , biophysics , medicine , biochemistry , biology
Nibufin, a paranitrophenyl ester of dibutylphosphinic acid, was synthesized at the Laboratory of Organic Chemistry. A.E. Arbuzov KHTI A.I. Razumov and O.A.Mukhacheva (1957). The drug was pharmacologically examined and proposed for practical use by IV Zaikonnikova (1961). As her studies have shown, nibufin has a pronounced anticholinesterase property, increases the tone of smooth muscle organs - the intestines, uterus, and enhances peristalsis. Compared with other organophosphorus compounds used in medicine - armin, phosphacol, phosarbin, it is much less toxic.