Open AccessSimplified calculation of genetic risk
Author(s) -
N. A. Sergeeva
Publication year - 1996
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj104632
Subject(s) - inheritance (genetic algorithm) , kinship , genetic counseling , disease , computer science , offspring , genetics , genealogy , mathematics , biology , medicine , gene , sociology , pregnancy , history , pathology , anthropology
Calculating the risk of transmitting a hereditary disease to offspring is important in the practice of medical genetic counseling. Most universal formulas are cumbersome, and their use assumes that the frequency of the mutant gene is already known or is calculated from special tables. Despite the complexity of the calculation procedure, it is necessary to determine the type of inheritance when using information only about sick family members and their kinship relations, taking into account the possibility of incomplete manifestation of the genotype.