Open AccessEffect of pyrimidine derivatives: Xymedone and diuciphone on bioenergetic processes of mitochondria
Author(s) -
Yu. D. Slabnov,
D. A. Valimukhametova,
И. Х. Валеева,
Р. С. Гараев
Publication year - 1996
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj104430
Subject(s) - mitochondrion , bioenergetics , respiration , stimulation , chemistry , oxidative phosphorylation , 2,4 dinitrophenol , rotenone , dinitrophenol , biochemistry , substrate (aquarium) , medicine , endocrinology , biology , anatomy , ecology
The stimulation of oxygen consumption in the presence of incubative medium just as excessive quantity of oxidation substrate, so oxidation phosphorylation disconnector of 2,4-dinitrophenol is shown on thymocytes of not pedigree he-rats obtaining xymedone (3 mg/kg and 30 mg/kg) and diuci phone (30 mg/kg) during 9 and 30 days. The effect of xymedone is dosedependent and more pronounced than the effect of diuciphone. The uniform effect of xymedone on mitochondrion respiration of thymocytes and isolated mitochondria of the liver is shown.