Open AccessEndolymphatic antibiotic therapy of local purulent process
Author(s) -
T. P. Lebedeva,
O. B. Begshiyev,
A. V. Konychev,
L. M. Vlasova
Publication year - 1989
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj101581
Subject(s) - antibiotics , flora (microbiology) , medicine , population , biology , microbiology and biotechnology , bacteria , genetics , environmental health
The increase in the number of patients with purulent diseases in the last decade is due to the allergization of the population, the increasing number of patients with diabetes mellitus, the appearance of associations of microbial flora with high virulence and the increasing number of antibiotic-resistant forms. To achieve a clinical effect, it is necessary to increase therapeutic doses of antibiotics, while they themselves are toxic and reduce immunity indicators, increasing the body's susceptibility to infection. With traditional methods of administration, antibiotics are not always able to inhibit the growth and reproduction of microorganisms. It is known that localization and spread of microorganisms occur mainly in the lymphatic system. Therefore, today the most rational and effective is the method of endolymphatic administration of antibiotics, which manages to create a sufficient concentration of antibiotic in the pyo-inflammatory focus and the surrounding tissues within 24 hours after a single therapeutic dose administration.