Open AccessExperimental pharmacotherapy of toxic brain edema by nonanticholinesterasic phosphoroorganic compounds
Author(s) -
R. H. Khafizyanova
Publication year - 1995
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj100634
Subject(s) - brain edema , edema , pharmacotherapy , pharmacology , medicine , nicotine , drug , anesthesia
Experimental study of the effect of dimephosphone, phosphabenzide, preparations № 305 and № 155 examples of various groups of synthetic nonanticholinesterasic phosphoroorganic compounds, on the development of toxic brain edema in rats, caused by injection of nicotine and monoiodacetate, reveal their antiedematic property. The results of investigations show prospects of a search of new effective medicinal agents for prevention and treatment of brain edema among phosphoroorganic compounds which do not show anticholinesttrasic activity.