Use of synthetic equivalents of dipolar [C2] 2/2+ -synthons for synthesis of biologically active heterocyclic assemblies with coumarin links

Within the synthon approach the analysis of synthetical potential of the dipolar [C2] 2/2+ - synthons is performed. The possible reaction pathways of cyclization of the dipolar electrophilic [C2]22+-synthons with the dipolar nucleophilic [SN]32-, [SN]42-, [CN]32-, [N2]32--synthons are determined. As synthetical equivalents of [C2]22+-synthons, 3-(-bromoacetyl) coumarins are chosen. On the basis of the new and improved methods of syntheseis two- and threelink biologically active assemlies of cycles with terminal coumarin links containing thriazole, indolizine, azoindolizine, 1, 3, 4-thiadiazine, furane, quinoxaline and oxazole rings are synthesized. The biological activity of 3-thiazolylcoumarins is investigated. It is stated that all of the compounds under investigation are low toxic and some of them manifest the pronounetd diuretic, antiinflammatory and membrane-stabilizing activities.