Open AccessCytokines production by mononuclear cells, infiltrating the epithelium tumour of ovaries
Author(s) -
Р. В. Павлов,
V. A. Aksionenko,
С. А. Сельков
Publication year - 2002
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd90024
Subject(s) - peripheral blood mononuclear cell , ovarian carcinoma , ovary , medicine , cytokine , malignancy , pathology , cancer research , interleukin , biology , ovarian cancer , immunology , cancer , in vitro , biochemistry
At auto serum presence one investigated IL1, IL2, IL4, IL6 and TNF6 production by mononuclear cells, infiltrating epithelium tumor of ovaries in 50 women of the patients by good-quality tumors, 30 patients by boundary tumors and 50 patients by an ovarian carcinoma.
It was established, that IL1, TNF6 and IL6 production by mononuclear cells, infiltrating epithelium tumour of ovary, grew at malignancy of good-quality tumors and decreased the differentiation degree of cells of ovarian carcinoma. At malignancy of good-quality tumours and decreasing differentiation degree of cells of ovarian carcinoma the decrease of spontaneous and stimulated production of IL2 and stimulated production of IL4 by mononuclear cells, infiltrating epithelian tumour of ovary is revealed.
The received data allow approving the increase of activity of mononuclear fagocytes, infiltrating epithelian tumor of ovarian during tumour progression, and also the decrease of T-cells activity in the 1-st and 2 types of immunity reactions in tumours of this localization.
One of the possible reasons of cells immunity decrease at a tissue level in ovarian tumour can be increased production of cytokines by mononuclears, closing immunity reactions, in particular IL6.