Role of atrial natriuretic peptide (ANP) in feto-placental and maternal circulation | Zendy

Andrei D. Polyanin | Zendy; I. Ju. Kogan | Zendy

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Role of atrial natriuretic peptide (ANP) in feto-placental and maternal circulation

Author(s) -

Andrei D. Polyanin,

I. Ju. Kogan

Publication year - 2002

Publication title -

journal of obstetrics and women s diseases

Language(s) - English

Resource type - Journals

eISSN - 1684-0461

pISSN - 1683-9366

DOI - 10.17816/jowd89948

Subject(s) - medicine , placental insufficiency , umbilical artery , fetus , preeclampsia , caesarean section , placenta , vaginal delivery , umbilical vein , diabetes mellitus , pregnancy , obstetrics , hypoxia (environmental) , cardiology , endocrinology , oxygen , biochemistry , genetics , chemistry , in vitro , biology , organic chemistry

ANPwas measured in maternal cubital vein (M), umbilical vein (UV) and artery (UA) in 39 women at term delivery (23 vaginal, 16 caesarean): 15 - normal pregnancy; 24 pregnancies were complicated by placental insufficiency, 14 - by preeclampsia, 10 - by diabetes mellitus. Blood gases and pH in UA, UV were measured. M, UA, UV ANPat caesarean section was similar to that in vaginal delivery (p0,05). In normal and complicated pregnancies, UA ANPwas significantly higher than ANPin M and UV. In pregnancies complicated by diabetes mellitus, UV ANPwas higher than ANPin UA (21, 93 fmol/l and 13, 03 fmol/l). In pregnancies complicated by acute placental insufficiency, UV ANPwas significantly lower than that in UA in normal pregnancy (p0,001). There is positive correlation between ANPconcentration and pH in UV. Fetus is capable of ANPproduction. ANPmay be synthesized in the placenta. Fetal hypoxia appears to be a potent stimulus for elevating of ANPplasma concentration.

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