Open AccessThe special biochemical measures to women with OPG-gestosis, having an artificial abortion in their anamnesis
Author(s) -
Л. А. Данилова,
V. K. Yaroslavskiy,
O. B. Basharina,
N. A. Chayka
Publication year - 2002
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd89939
Subject(s) - anamnesis , medicine , lipid peroxidation , pregnancy , abortion , methemoglobin , physiology , endocrinology , obstetrics , hemoglobin , biology , oxidative stress , genetics
The goal of the present work consists in usage of biochemical methods complex, which allow estimating the peculiarities of pregnancy current of women with OPG-gestosis, complicated by artificial abortion in their anamnesis. There were studied 45 pregnant women in the age 21-36 years with OPG-gestosis (20-firstpregnant - the 1-st group) and 25 - repeatedly-pregnant women, who had from 1 to 5 artificial abortions in their anamnesis (the 2-nd group) and 17 women with physiological pregnancy (control group). The intensity of lipid peroxidation was measured by level of a final product - malonic dialdehyde (MDA). Its concentration in erythrocytes and plasma was the highest (25 % and 34% accordingly) at 2-nd groupin comparison with control group. In addition, there were lipid the activity reduction of antioxidative system basic component - erytrocytes superoxidedysmutase (SOD) 11,8 - 12,74 % at all women with OPG- gestosis. Identical changes were observed relative to methemoglobin level and ammonium concentration in all women with OPG-gestosis (there were rise in 271-296 % and 35% accordingly, in comparison with control group). The rise of endogenous intoxication level correlated with decrease ones in plasma. Concentration of middle and low molecular mass of compounds in erythrocytes was higher in 14 and 9%, and was 13 and 6% lower in plasma accordingly in 1- st and 2-nd groups, in comparison with control. Analysis of data leads to a conclusion that pregnant woman with OPG-gestosis, complicated by artificial abortion in their anamnesis, and had more considerable changes of lipid peroxidation and endogenous intoxication level.