Open AccessCytokine production by peripheral blood lymphocytes in patients with ovarian epithelial tumors
Author(s) -
Р. В. Павлов,
В. А. Аксененко,
Alexander Krivoruchko,
Н. А. Павленко
Publication year - 2021
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd89004
Subject(s) - medicine , peripheral blood mononuclear cell , peripheral blood , ovarian cancer , cytokine , peripheral , tumor necrosis factor alpha , epithelial ovarian cancer , immunology , oncology , cancer , biology , in vitro , biochemistry
In presence of autoserum, production of IL1b, IL2, IL4, IL6 and TNFa by peripheral blood lymphocytes of 30 patients with epithelial tumors of ovaries and 50 patients with epithelial ovarian cancer of I-IV stages was investigated. The data received enable to ascertain the increase of mononuclear activity during ovarian tumor progression, increase of T-helpers of the second type activity, along with the reduction of T-helpers of the first type activity in peripheral blood of patients, and abnormalities of IL6-dependent mechanism of control of ILIb and TNFa production by peripheral blood lymphocytes of patients with ovarian cancer.