Open AccessDonors of nitric oxide in the treatment of preeclampsia: influence on the state of the endothelium and hemodynamics in the functional mother-placenta-fetus system
Author(s) -
Elena A. Malakhovskaya,
М. С. Зайнулина
Publication year - 2004
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd88641
Subject(s) - preeclampsia , isosorbide dinitrate , medicine , nitric oxide , hemodynamics , placenta , endothelium , thrombomodulin , fetus , cardiology , endothelial dysfunction , pregnancy , biology , thrombin , platelet , genetics
We investigated influence of nitrovasodilators on functional status of endothelium in preeclampsia with measuring of thrombomodulin, sICAM-1 and sVCAM-1 plasma levels. Changes in feto-placental and uteroplacental hemodynamics were analysed after treatment with isosorbide mononitrate and isosorbide dinitrate. Our results showed efficacy of nitric oxide donors in complex therapy of preeclampsia.