Open AccessAdenomyosis as an optional risk factor for uterine cancer
Author(s) -
D. F. Kostyuchek,
Н М Аничков,
Viktoriya Anatolyevna Pechenikova
Publication year - 2004
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd88606
Subject(s) - adenomyosis , medicine , endometrial cancer , malignant transformation , cancer , gynecology , pathology , endometriosis
The problem of adenomyosis malignization is controversial and insufficiently explored. Rate of the malignant transformation of adenomyosis varies from O.l to 24 per cent; as a rule, malignization of the stromal component of adenomyosis is described, works containing cancerous transformation description are isolated ones. Comparative clinical and morphological and immunohistochemical investigation of the cancerous transformation of adenomyosis (6 observations), endometrium cancer in combination with adenomyosis (16 observations), and typical adenomyosis (9 observations) is carried out. Obtained data indicate the precancerous optional significance of adenomyosis, risk of which increases in senior age groups. Endometrial adenocarcinoma does not exhibit a tendency to invasive growth into adenomyosis nidi; combined independent development of endometrium cancer and adenomyosis malignization with exo- and endophyte growth is possible, which determines the hypodiagnostics of malignizated adenomyosis. Morphological verification of malignizated adenomyosis demands comprehensive clinical and morphological investigation with broad study of operating material and with taking into consideration the stages of cancerous transformation morphogenesis established during the work. Late diagnostics and inadequate surgical treatment diagnose the unfavorable prognosis.