Open AccessHemostasis system and immunomorphologic state of placenta under presence of antiphospholipid antibodies in plasma with consideration of their class and pregnancy outcome
Author(s) -
Н. Г. Кошелева,
L. В. Zubzhitskaia,
О. Н. Аржанова,
О. В. Тышкевич,
Y. L. Gromyko,
Tatyaikolayevna Shlyakhtenko,
Т. А. Плужникова,
Elena A. Shapovalova
Publication year - 2004
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd86971
Subject(s) - medicine , hemostasis , lupus anticoagulant , pregnancy , antiphospholipid syndrome , gestation , platelet , antibody , placenta , miscarriage , obstetrics , anticardiolipin antibodies , autoantibody , immunology , fetus , biology , genetics
The present study was undertaken to investigate hemostasis system of 197 women with recurrent miscarriage: Analysis placentas by immunomorphology are studied of 41 women and of 52 women with autoimmune antibodies to 2-glycoprotein-I (2-GPI) in placenta. There was exposed hyperactivation platelets blood of all women with antiphospholipid antibodies irrespective of groups with significantly was increased at the beginning of pregnancy and progressed with growing gestation. As result of investigation it is determined certain connection between outcome of pregnancy and activation degree platelets blood in vasculars. Was found absence influence anticardiolipin antibodies (aCL) on plasmocoagulative link hemostasis. The circulation of lupus anticoagulant (LA) was accompanied indication of hypercoagulation. In all research groups was determined significant oppression of fibrinolisis. Analysis placentas by immunomorphology was determined significantly tissue damages with LA and 2-GPI-dependent aCL.