Dydrogesterone (duphaston) and its 20-dihydro- metabolite as selective modulators of estrogenic enzymes in human breast cancer cells | Zendy

Н. Н. Thole | Zendy; Gérard S. Chetrite | Zendy; Philippe Galéra | Zendy; Jörge R. Pasqualini | Zendy

Open Access

Dydrogesterone (duphaston) and its 20-dihydro- metabolite as selective modulators of estrogenic enzymes in human breast cancer cells

Author(s) -

Н. Н. Thole,

Gérard S. Chetrite,

Philippe Galéra,

Jörge R. Pasqualini

Publication year - 2005

Publication title -

journal of obstetrics and women s diseases

Language(s) - English

Resource type - Journals

eISSN - 1684-0461

pISSN - 1683-9366

DOI - 10.17816/jowd82486

Subject(s) - medicine , breast cancer , dydrogesterone , estrogen , metabolite , cancer , oncology , enzyme , cancer research , endocrinology , pharmacology , biochemistry , biology

The presented data open up interesting prospects for studying the biological responses of progestogens in clinical trials in patients with breast cancer. Estradiol is one of the main factors that control the growth and development of breast cancer. Therefore, an important goal of research in recent years is to block the formation of estradiol inside cancer cells.

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