Open AccessDydrogesterone (duphaston) and its 20-dihydro- metabolite as selective modulators of estrogenic enzymes in human breast cancer cells
Author(s) -
Н. Н. Thole,
Gérard Chetrite,
Philippe Galéra,
Jörge R. Pasqualini
Publication year - 2005
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd82486
Subject(s) - medicine , breast cancer , dydrogesterone , estrogen , metabolite , cancer , oncology , enzyme , cancer research , endocrinology , pharmacology , biochemistry , biology
The presented data open up interesting prospects for studying the biological responses of progestogens in clinical trials in patients with breast cancer. Estradiol is one of the main factors that control the growth and development of breast cancer. Therefore, an important goal of research in recent years is to block the formation of estradiol inside cancer cells.