Open AccessInfluence gene vdr3 genotypes and alleles on bone turnover in early postmenopausae
Author(s) -
Irina E. Zazerskaya,
М. В. Асеев,
L. V. Kuznetsova,
М. В. Москаленко,
Tatyna Ivashenko,
Vladislav Baranov
Publication year - 2005
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd81636
Subject(s) - bone remodeling , bone mineral , medicine , osteoporosis , genotype , menopause , endocrinology , allele , calcitriol receptor , physiology , bioinformatics , gene , genetics , vitamin d and neurology , biology
Studies on the genetics have focused on the regulation of bone mineral density (BMD) a major predictor of osteoporotic fracture risk. Evidence for a genetic contribution to BMD regulation comes primarily from twin studies thats hawed that between 5070 % of variance in BMD is caused by genetic factors. A great deal of research has been done on gene candidate VDR.3 on 176 postmenopausal women (108 natural menopause and 69 surgical menopause). Polymorphisms of vitamin D receptor have been associated in our group with the speed of bone turnover, registries by DEXA with interval 12 months and DDR test. The every second patient with genotype tt has chance to accompany group with osteoporosis in postmenopausae. In group of women with highs speed of bone turnover frequency t allel in 3 time more than in group with slow bone turnover.