Open AccessExperimental models of type 1 diabetes
Author(s) -
Maria I. Yarmolinskaya,
Ярмолинская Мария Игоревна,
Nelly Y. Andreyeva,
Андреева Нелли Юрьевна,
Elena I. Abashova,
Абашова Елена Ивановна,
Elena V. Misharina,
Мишарина Елена Владимировна
Publication year - 2019
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd682109-118
Subject(s) - medicine , type 2 diabetes , diabetes mellitus , disease , extrapolation , pathogenesis , animal model , bioinformatics , intensive care medicine , computational biology , endocrinology , biology , mathematics , mathematical analysis
This article describes currently used experimental animal models of type 1 diabetes. The literature data on the pathogenesis of clinical and morphological patterns of the disease and the possibility of extrapolation have been summarized in the review. In addition, the advantages and disadvantages of each of the models have been evaluated. Based on the reported results, it can be concluded that preclinical research is essential as fundamental basis for the investigation of type 1 diabetes mellitus.