Informative capacity to assess cytokine status in predicting placental abruption

The purpose - to define a predictive role of the content in serum of blood of pregnant women of factor of a necrosis of a tumor - an alpha and interleykin-10 in development of a premature abruption of placenta. Technique. The main group (n = 14) - patients from a premature abruption of placenta in terms of gestation of 22-41 week. Group of comparison (n = 30) - the patients who entered into group of risk on development of a premature abruption of placenta, but pregnancy and which childbirth proceeded without this pathology. Conclusions: 1. At patients from a premature abruption of placenta the contents the FNO-alpha in terms of pregnancy of 21-22 weeks and in 27-28 weeks prevails. Distinction in the contents Il-10 in the compared groups statistically isn’t reliable. 2. The assessment of the predictive importance of definition of cytokin in terms of gestation of 21-22 weeks revealed that for AUC 0,77 FNO-alpha that testifies to high quality of this diagnostic indicator as a predictor of a premature abruption of a placenta. For IL-10 AUC 0,65 - average quality of diagnostic test. In the analysis of predictive value of cytokin in the term of a gestation of 27-28 weeks it is defined that AUC for the FNO-alpha is equal 0,79 - high quality of diagnostic test. AUC for IL-10 0,54, is an unsatisfactory quality of diagnostic test.