Hyperhomocysteinemia in miscarriage: biochemical and genetic aspects | Zendy

Olesya N. Bespalova | Zendy

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Hyperhomocysteinemia in miscarriage: biochemical and genetic aspects

Author(s) -

Olesya N. Bespalova

Publication year - 2015

Publication title -

journal of obstetrics and women s diseases

Language(s) - English

Resource type - Journals

eISSN - 1684-0461

pISSN - 1683-9366

DOI - 10.17816/jowd64522-31

Subject(s) - medicine , methylenetetrahydrofolate reductase , mtrr , hyperhomocysteinemia , miscarriage , homocysteine , recurrent miscarriage , placenta , pregnancy , obstetrics , genotype , gynecology , bioinformatics , genetics , gene , fetus , biology

Elevated levels of homocysteine in the blood is an important marker of the occurrence of various obstetric pathology. As a result of hyperhomocysteinemia impairs processes of microcirculation in the placenta. This in turn can lead to defects of implantation resulting in miscarriage. One of the factors contributing to the increase in the level of homocysteine in the blood is a hereditary predisposition. The purpose of this study is to analyze the influence of gender, age, number of spontaneous miscarriages, the genotype of MTHFR and MTRR genes with folate cycle homocysteine in the blood, the couple with miscarriages.

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