Open AccessHyperhomocysteinemia in miscarriage: biochemical and genetic aspects
Author(s) -
Olesya N. Bespalova,
Беспалова Олеся Николаевна
Publication year - 2015
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd64522-31
Subject(s) - medicine , methylenetetrahydrofolate reductase , mtrr , hyperhomocysteinemia , miscarriage , homocysteine , recurrent miscarriage , placenta , pregnancy , obstetrics , genotype , gynecology , bioinformatics , genetics , gene , fetus , biology
Elevated levels of homocysteine in the blood is an important marker of the occurrence of various obstetric pathology. As a result of hyperhomocysteinemia impairs processes of microcirculation in the placenta. This in turn can lead to defects of implantation resulting in miscarriage. One of the factors contributing to the increase in the level of homocysteine in the blood is a hereditary predisposition. The purpose of this study is to analyze the influence of gender, age, number of spontaneous miscarriages, the genotype of MTHFR and MTRR genes with folate cycle homocysteine in the blood, the couple with miscarriages.