Open AccessОpioid analgesics effects mechanisms on the particular reaction of endogenous opioid system of the body and the regulation of uterine activity during the nociceptive response in the experiment on rats
Author(s) -
Andrey Gennadyevich Kiselev,
А. А. Зайцев
Publication year - 2015
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd64311-17
Subject(s) - medicine , opiate , nociception , opioid , morphine , endogenous opioid , pharmacology , endogeny , analgesic , enkephalin , anesthesia , receptor
This article presents the results of experimental investigation of opioid (opiate analgesics) influence on the nociceptive response of rat’s circulatory dynamics, breath and skeletal muscles tonus. The article demonstrates influence of opiate analgesics on intact and pregnant rat’s amplitude and frequency of uterine activity. The results of investigation of drug-induced effect of opiate analgesics in case of pregnant and in case of act of delivery model pain reaction were also described in this article.