Open AccessImmunocytochemistry in diagnostics of endometrial precancer
Author(s) -
Tatyana Ivanovna Dzyubiy,
Дзюбий Татьяна Ивановна,
Anna E. Protasova,
Протасова Анна Эдуардовна,
Г. А. Раскин,
Раскин Григорий Александрович,
Anna A. Tsypurdeyeva,
Цыпурдеева Анна Алексеевна,
Natalya I. Tapilskaya,
Тапильская Наталья Игоревна
Publication year - 2013
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd62535-40
Subject(s) - medicine , atypia , pten , immunocytochemistry , hyperplasia , endometrium , endometrial hyperplasia , pathology , endometrial cancer , differential diagnosis , cancer , biology , microbiology and biotechnology , signal transduction , pi3k/akt/mtor pathway
Use of the method liquid-based cytology with next immunocytochemical study of endometrium is expedient for the differential diagnosis of endometrial pathology processes. The level of the gene PTEN and steroid receptors expression is higher in cases of simple hyperplasia and hyperplasia without atypia. Increase of the markers p53 and Ki67 expression was found only by atypical endometrial hyperplasia. Positive reaction on CD138 determines the inflammatory process.