Open AccessEfficiency of gonadotropin-releasing hormone analogue in endometriosis therapy
Author(s) -
Valentina Mikhaylovna Denisova,
Денисова Валентина Михайловна
Publication year - 2013
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd62529-34
Subject(s) - aromatase , letrozole , endometriosis , medicine , estrogen , estrone , endocrinology , hormone , prolactin , aromatase inhibitor , menstrual cycle , cancer , breast cancer
Endometriosis is estrogen- dependent disease. Aromatase P450 is the key enzyme in estrogen biosynthesis. The aim of the study was to compare therapeutic efficiency of gonadotropin-releasing hormone analogue (aGnRH) with ovarian aromatase activity. 64 women with endometriosis were examined after laparoscopic coagulation of endometrioid lesions. The examination included determination of FSH, LH, prolactin, antimüllerian hormone, estradiol, estrone and androstendione by immune-enzyme assay in peripheral blood and determination of ovarian aromatase activity by test with aromatase inhibitor letrozole. Laparoscopic coagulation of endometrioid lesions and following six- month course of aGnRH have lead to decrease of clinical manifestations of the disease and recovery of normal ovulatory menstrual cycle in most (72.5 %) of the patients. Therapeutic efficiency of combined therapy did not depend on basal blood estradiol level and ovarian aromatase activity.