Open AccessDifferentiation of memory cells in the T-helper subset during normal pregnancy andpreeclampsy
Author(s) -
A. V. Kudryashova,
Кудряшова Анна Влдимировна,
N. Yu. Sotnikova,
Сотникова Наталья Юрьевна,
И.А. Панова,
Панова Ирина Александровна,
Lyudmila Viktorovna Kadyrova,
Кадырова Людмила Викторовна
Publication year - 2013
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd622110-116
Subject(s) - pregnancy , medicine , gestation , population , first trimester , second trimester , peripheral blood , third trimester , immunology , biology , genetics , environmental health
The amount of Th1и and Th2 cells in the peripheral blood increased in the first trimester and remained at the high level during all the process of gestation. Changes in the quantity of memory cells were defined: by the enhanced level of Temra in the CD4+ subset and of IFNγ+ cells in the population of CD4+ Temra in the second trimester; by restoring the balance of Tcm, Tem and Temra to the values of nonpregnant donors in the third trimester. In preeclampsy pregnancy the level Th1, Th2 and IFNγ+ cells in CD4+ population of Temra was significantly higher then in normal pregnancy.