EFFICACY OF GONADOTROPIN-RELEASING HORMONE AGONISTS TREATMENT OF THE SIMPLE ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE WITH OBESITY | Zendy

Н В Артымук | Zendy; Yelena Aleksandrovna Shakirova | Zendy

Open Access

EFFICACY OF GONADOTROPIN-RELEASING HORMONE AGONISTS TREATMENT OF THE SIMPLE ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE WITH OBESITY

Author(s) -

Н В Артымук,

Yelena Aleksandrovna Shakirova

Publication year - 2013

Publication title -

journal of obstetrics and women s diseases

Language(s) - English

Resource type - Journals

eISSN - 1684-0461

pISSN - 1683-9366

DOI - 10.17816/jowd62116-21

Subject(s) - medicine , desogestrel , gonadotropin releasing hormone agonist , endometrial hyperplasia , ethinylestradiol , obesity , gonadotropin releasing hormone , estrogen , endocrinology , gynecology , hormone , hyperplasia , population , family planning , luteinizing hormone , environmental health , research methodology

A prospective, randomized, open, comparative study. There were 105 women of reproductive age with obesity and simple endometrial hyperplasia without atypia (EH) included into the study. 13 patients had left the study.31 patients took an agonist of gonadotropin-releasing hormone (aGnRH) Buserelin at the dose of 3.75 mg intramuscularly every 28 days. 33 patients took 10 mg of norethisteron per day. 28 patients took combined estrogen-gestagen drugs (30 mkg of ethinylestradiol + 150 mkg of desogestrel). The base therapy of obesity (a balanced diet and a physical activity)had been administered to all of the patients. Treatment in all groups lasted 6 months. The results of this study showed that usage of aGnRH in management of endometrial hyperplasia in patients of reproductive age with obesity is most effective and safe.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research