Open AccessNoninvasive prenatal diagnostic. Problems, approaches and perspectives
Author(s) -
Olga Malysheva,
Vladislav Baranov
Publication year - 2012
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd61383-93
Subject(s) - cell free fetal dna , medicine , sexing , fetus , prenatal diagnosis , obstetrics , peripheral blood , pregnancy , bioinformatics , immunology , genetics , biology
In the review possibilities of noninvasive prenatal diagnostics on DNA of a fetus circulating in peripheral blood of pregnant woman are discussed. Characteristics cell-free (cf) DNA of plasma and fetus cfDNA (cffNA), circulating in a parent blood-groove are resulted. Methodical approaches to extraction and analysis cffDNA are considered. Possibilities and restrictions of application of a method for fetal sexing and fetal Rhesus factor detection, and also prospect of noninvasive diagnostics of the most frequent aneuploidies are discussed