Noninvasive prenatal diagnostic. Problems, approaches and perspectives | Zendy

Olga Malysheva | Zendy; В. С. Баранов | Zendy

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Noninvasive prenatal diagnostic. Problems, approaches and perspectives

Author(s) -

Olga Malysheva,

В. С. Баранов

Publication year - 2012

Publication title -

journal of obstetrics and women s diseases

Language(s) - English

Resource type - Journals

eISSN - 1684-0461

pISSN - 1683-9366

DOI - 10.17816/jowd61383-93

Subject(s) - cell free fetal dna , medicine , sexing , fetus , prenatal diagnosis , obstetrics , peripheral blood , pregnancy , bioinformatics , immunology , genetics , biology

In the review possibilities of noninvasive prenatal diagnostics on DNA of a fetus circulating in peripheral blood of pregnant woman are discussed. Characteristics cell-free (cf) DNA of plasma and fetus cfDNA (cffNA), circulating in a parent blood-groove are resulted. Methodical approaches to extraction and analysis cffDNA are considered. Possibilities and restrictions of application of a method for fetal sexing and fetal Rhesus factor detection, and also prospect of noninvasive diagnostics of the most frequent aneuploidies are discussed

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