Open AccessFeatures of the gene polymorphism of estrogen and progesterone receptors in women with uterine leiomyoma
Author(s) -
Natalya Sergeevna Osinovskaya,
T. Ivaschenko,
Lyailya Kh. Dzhemlikhanova,
Vladislav Baranov,
А. Н. Ткаченко,
Iskender Yuryevich Sultanov
Publication year - 2012
Publication title -
žurnalʺ akušerstva i ženskihʺ boleznej
Language(s) - English
Resource type - Journals
eISSN - 1684-0461
pISSN - 1683-9366
DOI - 10.17816/jowd613109-114
Subject(s) - myometrium , uterine leiomyoma , leiomyoma , progesterone receptor , estrogen , estrogen receptor , endocrinology , medicine , estrogen receptor alpha , population , receptor , endometrium , uterus , biology , pathology , cancer , breast cancer , environmental health
Uterine Leiomyoma (Leiomyoma) (LM) — benign and most common (incidence 20–45 %) hormone-dependent tumors of female genital organs. Comparative analysis of frequencies of polymorphic variants of genes of estrogen receptor (ERα) and progesterone receptor (PGR) in patients with LM and the population samples was conducted in this work. Also it was investigated their association with clinical manifestation of hyperplastic processes of the female reproductive system. It was founded that the development of LM are not associated with individual polymorphic variants of genes of estrogen receptor and progesterone receptor. This fact does not include their participation in the development of proliferative and hyperplastic processes of the myometrium