On the question of uterine-ovarian function in connection with menstrual and climacteric phenomena in the female body

At the present time, enough evidence has accumulated to indicate that the role of the ovaries is not limited exclusively to the preparation of the egg cell. Clinical observations of women with castrates in general and the beneficial effect of castration on the course of osteomalacia in particular have long led to the idea that the ovaries, like other glands of the body, also have a special, internal secretion, that is, the ovaries, in addition to producing an egg cell, release a special chemical into the blood the beginning, taking a very active part in the metabolism.