Open AccessINTERDISCIPLINARY APPROACH TO THE SYNDROME OF ACUTE HEPCENARY FAILURE
Author(s) -
Vera B. Tetova,
О А Бургасова,
В М Волкова,
N. M. Belyaeva
Publication year - 2017
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40977
Subject(s) - medicine , intensive care medicine , coagulopathy , liver transplantation , encephalopathy , mortality rate , liver failure , transplantation , survival rate , liver function , pediatrics
In the review the data concerning an etiopathogenesis and clinical manifestations of the acute liver failure (ALF) and also potential options of alternative treatment are considered: Orthotopic transplantation of liver and modern approaches to patient maintenance. The ALF syndrome, despite the progress in the intensive therapy modes, represents a clinical syndrome with the high mortality rate. In healthy adults, especially in cases aged of up to 30 years ALF syndrome represents a significant intredisciplinary problem in terms of diagnostics and maintenance tactics. The clinical picture is most often presented by the hepatic dysfunction, development of a coagulopathy and change of biochemical indices of the liver function, with the development of encephalopathy and polyorganic insufficiency. The lethality rate in this syndrome reaches 50%. The high mortality rate, severity of the course, etiologic heterogeneity causes the need of the development of standards for the supporting therapy. Thanks to achievements in the field of the intensive therapy and the use of the emergency transplantation of a liver allograft survival indices have considerably been improved in recent years.