Open AccessTHE LEVEL OF SPONTANEOUS AND INDUCED Γ-INTERFERON IN FLU AND RESPIRATORY-SYNСITIAL INFECTIONS
Author(s) -
И П Баранова,
I. A. Malova
Publication year - 2017
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40964
Subject(s) - etiology , interferon , medicine , pathogen , polymerase chain reaction , virus , virology , immunology , biology , gene , biochemistry
This article presents results of the analysis of the level of spontaneous and induced γ-interferon in patients hospitalized in the Department of infectious diseases of the Medical Sanitary Unit No. 59 of the settlement Zarechny (the Penza region). The study included 64 in-patients of the infectious hospital including influenza cases, predominantly, (N3N2) - 27%, influenza B - 22%, RS-virus infection - 28%, unverified pathogen - 23%. Verification of etiological SARS was carried out through the identification of RNA and DNA viruses in nasal and pharyngeal discharges, polymerase chain reaction (PCR) method was used in real time. The level of spontaneous γ-interferon (IFA method) before and after treatment was shown to be low and ranged from 0,0 to 4,9 pg/ml, irrespective of etiology, age and gender. The level of induced γ-interferon in flu before the treatment was significantly higher, than in RS infection. In schoolchildren and adults levels of induced γ -interferon before and after the treatment were significantly higher than in preschool children.