Open AccessAntigen-presenting activity of dendritic cells in patients with chronic hepatitis C genotype
Author(s) -
V. V Tsvetkov,
О. И. Киселев,
Т. В. Сологуб,
Alexander V. Slita,
И. И. Токин,
E. S Anhimova
Publication year - 2015
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40882
Subject(s) - antigen , immunology , antigen presentation , immune system , human leukocyte antigen , genotype , chronic hepatitis , major histocompatibility complex , medicine , biology , virology , virus , t cell , gene , genetics
Dendritic cells (DC) are the most professional antigen presenting cells, which are the first to recognize the «danger signals» and trigger highly specific immune responses. However, the results ofstudies performed by some foreign and domestic authors, testify to a violation of the functional activity of DCs in patients with chronic hepatitis C (CHC). In order to study the nature of the clinical course of various forms of CHC and for the assessment of the capability of DC to antigen presentation in the 2014-2015 in «Research Institute of Influenza» there was performed a simple comparative clinical study. DC obtained from patients with CHC were found to have high antigen-presenting activity due to the presence on their surface a high level of the expression of MHC class I and II. The maturation of DC is accompanied by a significant increase in the levels of expression of HLA-A, B, C and HLA-DR, irrespective of the degree of liver fibrosis, biochemical activity of alanine aminotransferase or level of viral load.