Open AccessPeculiarities of cellular immunity in acute Epstein-Barr virus infection
Author(s) -
A. A Trisko,
Н. В. Колесникова,
Marina G. Avdeeva,
Г. А. Чудилова,
Л В Ломтатидзе
Publication year - 2015
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40856
Subject(s) - mononucleosis , immunology , immunity , virus , acute tonsillitis , cellular immunity , virology , epstein–barr virus infection , epstein–barr virus , immune system , cd19 , cd8 , medicine , tonsillitis , biology , pathology
With the aim of the optimization of the differential diagnosis there was performed an assessment of cellular immunity in patients with acute viral (infectious mononucleosis associated with Epstein-Barr virus) and acute bacterial infection (bacterial tonsillitis). Study groups was consisted of 22 patients with infectious mononucleosis, the comparison group - 19 patients with acute bacterial tonsillitis. There was revealed a number of significant changes typical for acute infectious process of various etiology. The features of cellular immunity in acute viral infection in terms of EBV-associated infectious mononucleosis are: the increase of cytotoxic CD8(+) - T-cells; consistent deficiency ofpopulations and subpopulations of CD19 (+) - B lymphocytes; a significant increase in density (MFI) expression of CD19-, CD21-, CD81-receptors in various subpopulations ofB lymphocytes. Revealed regularities of changes in cellular immunity in acute Epstein-Barr virus infection are caused by biological characteristics of the pathogen and can be used for the optimization of the laboratory diagnosis of infectious mononucleosis.