z-logo
open-access-imgOpen Access
Peculiarities of cellular immunity in acute Epstein-Barr virus infection
Author(s) -
A. A Trisko,
Н. В. Колесникова,
Marina G. Avdeeva,
Г. А. Чудилова,
Л В Ломтатидзе
Publication year - 2015
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40856
Subject(s) - mononucleosis , immunology , immunity , virus , acute tonsillitis , cellular immunity , virology , epstein–barr virus infection , epstein–barr virus , immune system , cd19 , cd8 , medicine , tonsillitis , biology , pathology
With the aim of the optimization of the differential diagnosis there was performed an assessment of cellular immunity in patients with acute viral (infectious mononucleosis associated with Epstein-Barr virus) and acute bacterial infection (bacterial tonsillitis). Study groups was consisted of 22 patients with infectious mononucleosis, the comparison group - 19 patients with acute bacterial tonsillitis. There was revealed a number of significant changes typical for acute infectious process of various etiology. The features of cellular immunity in acute viral infection in terms of EBV-associated infectious mononucleosis are: the increase of cytotoxic CD8(+) - T-cells; consistent deficiency ofpopulations and subpopulations of CD19 (+) - B lymphocytes; a significant increase in density (MFI) expression of CD19-, CD21-, CD81-receptors in various subpopulations ofB lymphocytes. Revealed regularities of changes in cellular immunity in acute Epstein-Barr virus infection are caused by biological characteristics of the pathogen and can be used for the optimization of the laboratory diagnosis of infectious mononucleosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here