Open AccessApplication of immunoassay systems for diagnosis of dengue fever
Author(s) -
Yu. A Akinshina,
Акиншина Юлия Александровна,
В. Ф. Ларичев,
Ларичев Виктор Филиппович,
С. Г. Марданлы,
Марданлы Сейфаддин Гашимович,
А. М. Бутенко,
Бутенко Александр Михайлович,
N. V. Khutoretskaya,
Хуторецкая Н. В,
М. А. Сайфуллин,
Сайфуллин Мухамад Абдулфаритович
Publication year - 2015
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40851
Subject(s) - dengue fever , flavivirus , virology , encephalitis , antibody , tick borne encephalitis , immunology , immunoassay , medicine , yellow fever , immunoglobulin m , immunoglobulin g , virus
As a result of the application of experimental test systems "ELISA-IgM-dengue", "ELISA-IgM-WN" and "ELISA-IgM-TBE" when examining sera from patients with dengue fever (DF), West Nile fever (WNF) and tick-borne encephalitis (TBE) there was established the possibility of a clear differential diagnosis of these related flavivirus infections. Application of the ELISA-IgG test systems fail to provide such an opportunity due to cause of pronounced cross-reactions of group-IgG antibodies. In the article there are presented data on dynamics of IgM and IgG antibodies in patients with dengue fever. Detection of specific IgG in the first days of the disease may indicate to a secondary nature of infection and the possibility of the development of hemorrhagic syndrome.