Open AccessModern possibilities for the prediction of the efficacy of antiviral therapy of chronic hepatitis C
Author(s) -
A. M. Ryumin,
Рюмин Александр Михайлович,
О. В. Корочкина,
Корочкина Ольга Владимировна,
Д. М. Собчак,
Собчак Девора Михайловна,
O. L Sobolevskaya,
Соболевская Оксана Львовна,
Т.Yu. Butina,
Бутина Татьяна Юрьевна,
И. В. Кузнецова,
Кузнецова Ирина Васильевна,
E. G Koreyvo,
Корейво Елена Германовна
Publication year - 2015
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40850
Subject(s) - chronic hepatitis , antiviral therapy , medicine , population , genotype , immunology , virology , gene , virus , biology , genetics , environmental health
Despite numerous investigations, the problem ofpredicting of efficiency of the antiviral therapy of chronic hepatitis C (CHC) remains to be actual. As recent investigations showed polymorphism of IL-B28 gene in large part determines the achievement of the sustained virological response. In this study in 70 CHC patients there were evaluated factors which influence on the results of the treatment, their occurrence in the population, and the use the control them as a predictor of the efficacy of the therapy. There is considered the possibility of correction of some of them. This allows you to predict the achievement of sustained virological response. There has been confirmed the need for the accounting of IL-B28 gene polymorphism in the relation to the wide spread occurence in the population of normal genotypes in loci Rs12979860 and Rs8099917.