Open AccessThe role of Helicobacter pylori in the process of 43 carcinogenesis by means of dysregulation of miRNA expression
Author(s) -
Olga Belaia,
Белая Ольга Федоровна,
E. V Volchkova,
Волчкова Елена Васильевна,
O. A Paevskaya,
Паевская Ольга Александровна,
S. N Zuevskaya,
Зуевская Светлана Николаевна,
Yu. V. Yudina,
Юдина Юлия Владимировна,
S. G Pak,
Пак Сергей Георгиевич
Publication year - 2014
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40847
Subject(s) - helicobacter pylori , carcinogenesis , microrna , cancer , gastritis , helicobacter , biology , stomach cancer , disease , neoplastic transformation , stomach , adenocarcinoma , chronic gastritis , cancer research , immunology , medicine , gene , genetics
Duodenal ulcer is associated with Helicobacter pylori almost in 90-100% of cases. Severe disease of the stomach - adenocarcinoma - is caused by infection with Helicobacter pylori in 70-90% of cases. Persons infected with this bacterium were proven statistically to be in group of the increased risk of the development of gastric cancer. Helicobacter pylori expresses a spectrum of virulence factors which cause dysregulation of intracellular signaling pathways in a host cell, that reduces the resistance to neoplastic transformation. In the review there are presented data about identified to the present time deregulated miRNAs associated with H.pylori diseases, including cancer of the stomach, and a few data on their biological significance. The growing number of studies confirming the involvement of miRNAs in various stages of carcinogenesis - from gastritis to the formation of metastases - demonstrates the importance of the new directions of the research.