Open AccessOn the question of pathogenesis of in chronic HCV-infection
Author(s) -
Marina G. Avdeeva,
I. V. Lysenko
Publication year - 2014
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40792
Subject(s) - immunology , immune system , anemia , hemolysis , pathogenesis , medicine , chronic infection , haematopoiesis , biology , stem cell , genetics
In a review of the literature there are considered the problems of hematopoiesis in HCV-infection and discussed the different mechanisms of anemia. On the basis of the analysis of current evidence it was shown that anemia in chronic hepatitis C may have hyporegenerative character and be associated with myelosuppressive effect of viral infection (directly or indirectly through a change in cytokine profile), it has features of the so-called anemia of chronic diseases, or be regenerative as a consequence of chronic blood loss, immune and non-immune hemolysis, microangiopathies, hypersplenism. In the formation of anemia there are important factors: the development of iron deficiency and/or vitamin BI2 deficiency, the effects of alcohol, and hormonal perturbations. The mactocytes presence in the peripheral blood is shown to be one of the characteristics of hematopoiesis during HCV-infection.