Open AccessEFFECTIVENESS OF DOMESTIC ANTIRETROVIRAL NRTI CLASS DRUG IN THE MONOTHERAPY OF HIV INFECTION
Author(s) -
N. N. Vorobiova,
Воробьева Наталья Николаевна,
Е. С. Иванова,
Иванова Эльвира Сергеевна
Publication year - 2013
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40760
Subject(s) - antiretroviral drug , medicine , viral load , human immunodeficiency virus (hiv) , drug , antiretroviral therapy , immunology , clinical trial , retrospective cohort study , combination therapy , pharmacology
The effectiveness of domestic preparation Phosphazide was proved during the performance of the retrospective analysis of a clinical case of monotherapy in a 28-year-old female with HIV infection. Phosphazide was prescribed after the achievement of virological and immunological effect of combined schedules of antiretroviral therapy. The dynamics of CD4 lymphocytes, plasma HIV RNA [viral load test (VL)] were followed up every 3 months for 372 weeks. The persistent decline in VL and keeping it at the level less than 3,79 log10 in combination with a positive clinical effect - the lack both of symptoms of progression of HIV infection and the development of opportunistic infections, stable level of CD4-lymphocytes> 500 cells/mcl can be considered as a positive result of monotherapy with Phosphazide.