Open AccessNEW PERSPECTIVES OF PERSONALIZED THERAPY OF CHRONIC HEPATITIS C
Author(s) -
Г. В. Сапронов,
Сапронов Георгий Витальевич,
Л. И. Николаева,
Николаева Людмила Ивановна
Publication year - 2013
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40719
Subject(s) - ns5a , ribavirin , chronic hepatitis , medicine , interferon , antiviral therapy , virology , viral hepatitis , hepatitis c , protease , protease inhibitor (pharmacology) , viral load , pharmacology , bioinformatics , hepatitis c virus , hepacivirus , virus , biology , enzyme , biochemistry , antiretroviral therapy
The aim of this review - to analyze the possibilities of traditional therapy and opening new perspectives and approaches to personalized theraру of patients with chronic viral hepatitis C. There are considered the viral and patien tfactors that have an mpact on the efficacy of theтру with interferon-a2 and ribavirin. There are presented data on the molecular mechanism of action of these drugs preparations. There are considered new antiviral drugs (protease inhibitors) and pharmacological agents being under development and targeted to viral polymerase andprotein NS5A.