Open AccessImmunological indices in flu patients
Author(s) -
Н. В. Свистунова,
И П Баранова
Publication year - 2012
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40692
Subject(s) - etiology , medicine , incidence (geometry) , immunology , cytokine , proinflammatory cytokine , alpha (finance) , disease , tumor necrosis factor alpha , pregnancy , biology , inflammation , surgery , construct validity , physics , genetics , optics , patient satisfaction
The results of the analysis of immunological features of influenza during the epidemic rise in incidence are presented. In 39 patients aged from 8 to 34 years with moderate disease course changes in the serum concentration of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) and levels of production of interferons alpha and gamma (IFN = alpha and IFN=gamma) at beginning of the disease and in early recovery period were studied. The features and differences of the cytokine response during influenza in dependence on the etiology of the disease, presence of complications, gender, age of the patient, in women during pregnancy, as well as the various types of causal treatment have been revealed. Based on the characteristics of the dynamic fluctuations in the concentration of IFN-alpha, IFN gamma =, TNF-alpha in flu patients predictors of adverse clinical course are identified.