Open AccessDengue fever in the Russian Federation in travelers, returning from Southeast Asia in 2010-2011
Author(s) -
S. A. Berillo,
О. К. Демина,
V. A. Ternovoy,
А. Н. Шиков,
Е. И. Сергеева,
Anna Vladimirovna Demina,
N. E. Kostina,
Анна Викторовна Винокурова,
В. Н. Михеев,
А. П. Агафонов,
А. Н. Сергеев
Publication year - 2012
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40635
Subject(s) - dengue fever , dengue virus , medicine , differential diagnosis , antibody , yellow fever , immunoassay , virology , titer , immunology , travel medicine , pediatrics , virus , pathology
The aim of the work was the study of serum from patients with suspected dengue fever by both enzyme immunoassay and immunochromatography. Markers of dengue fever were detected in 6 of 10 travelers returning from Southeast Asia. Analysis of the of immunoglobulin M and G antibody titers ratio (IgG/IgM) showed that the five travelers were infected with dengue fever virus for the first time. At the same moment one of patients was infected with dengue virus repeatedly that is a risk factor for severe complications. Thus, early laboratory diagnosis of dengue based on the detection of NSl=antigen and IgG/IgM ratio has been shown not only to help in making a differential diagnosis, but also in saving the life of the patient, because the dengue fever is characterized by rapid progression to the development of severe complications which are not compatible with life. In cases of fever in travelers which have been coming back from countries where hemorrhagic fever is endemic, we propose to make a differential diagnosis with dengue fever that was confirmed by our study.