Open AccessFeatures of papillomavirus infection in HIV-infected women
Author(s) -
Е. С. Свердлова,
Свердлова Елена Семеновна,
Т.В. Дианова,
Дианова Татьяна Валерьевна
Publication year - 2012
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.17816/eid40631
Subject(s) - cervical intraepithelial neoplasia , medicine , cervical cancer , human papillomavirus , stage (stratigraphy) , human immunodeficiency virus (hiv) , incidence (geometry) , hpv infection , oncology , cancer , immunology , immune system , gynecology , biology , paleontology , physics , optics
As participation of immune system in the protection of human papillomavirus (HPV) has been proven, the incidence of HPV infection leading to cervical intraepithelial neoplasia (CIN) among HIV-positive women is 4 times higher than in HIV-negative cases. In the presence of HIV HPV implements oncoprogram during 6-12 months. Сytokine imbalance makes a significant contribution to the progression of HIV in combination with HPV. The criteria of selection of patients with HIV for therapy cytokines in CIN 2-3 (Roncoleukin used in the author's scheme). Using Ronkoleukin in combination with HAART in HIV-positive women can delay the progression of CIN 2-3 in cervical cancer. The criteria of selection of HIV female patients for the therapy with cytokines at the 2-3 stage of CIN ( Roncoleukin was used in the author's scheme) have been detected. Application Roncoleukin in combination with HAART in HIV-positive women can delay the progression of cervical cancer at the CIN 2-3 stage.