Polymorphism of DNA repair genes (XRCC1, XRCC3, XPD, XPC) and risk of uterine myoma among women working in petrochemical complex | Zendy

Olga V. Kochenova | Zendy; М К Гайнуллина | Zendy; Т. V. Victorova | Zendy

Open Access

Polymorphism of DNA repair genes (XRCC1, XRCC3, XPD, XPC) and risk of uterine myoma among women working in petrochemical complex

Author(s) -

Olga V. Kochenova,

М К Гайнуллина,

Т. V. Victorova

Publication year - 2011

Publication title -

ecological genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.148

H-Index - 3

eISSN - 2411-9202

pISSN - 1811-0932

DOI - 10.17816/ecogen9443-51

Subject(s) - xrcc1 , xrcc3 , ercc2 , minor allele frequency , genotype , dna repair , biology , allele , nucleotide excision repair , genetics , xeroderma pigmentosum , gene , single nucleotide polymorphism , gene polymorphism

Uterine myoma is a multifactorial disease in which the development involving both genetic and environmental factors. In this study we analyzed polymorphisms of genes excision repair (XRCC1, XPD/ERCC2, XPC) and repair of double-stranded DNA breaks (XRC 3) among women working at a large petrochemical complex of "Salavatnefteorgsintez". It is established that a minor allele homozygous for the minor allele genotype and polymorphism Gln939Lys (rs2228001) XPC gene are associated with the risk of uterine myoma (OR = 3.9 CI 1.001-18.13 for genotype and OR = 2.3 CI 1.36-3.77 for allele).

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